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Succinyl phosphonate
CAS No. 26647-82-5
Succinyl phosphonate( —— )
Catalog No. M33130 CAS No. 26647-82-5
Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC?) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSuccinyl phosphonate
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NoteResearch use only, not for human use.
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Brief DescriptionSuccinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC?) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation.
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DescriptionSuccinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits(KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite | ROS
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Research Area——
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Indication——
Chemical Information
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CAS Number26647-82-5
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Formula Weight182.07
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Molecular FormulaC4H7O6P
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)CCC(=O)P(=O)(O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.?
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